Components Essential for the Generation of Germinal Centers
نویسندگان
چکیده
The present discussion reviews the minimal requirements for germinal center (GC) production. Among the components needed to produce these typical in vivo structures are (1) antigen (Ag with epitopes recognized by T cells), (2) B cells specific for the Ag, and (3) CD4 T cells.
منابع مشابه
gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory
gp39, the ligand for CD40 expressed on activated CD4+ T helper cells, is required for the generation of antibody responses to T-dependent (TD) antigens. Treatment of mice with anti-gp39 in vivo inhibits both primary and secondary antibody formation to TD, but not T-independent antigens. However, the role of this receptor-ligand pair in the development of germinal centers and the generation of B...
متن کاملBiology of germinal centers in lymphoid tissue.
Germinal centers in lymphoid tissue are the sites of generation of memory B cells undergoing isotype switching and somatic mutation in their Ig genes. Their formation cannot be induced by stimuli other than immunogenic ones. It seems likely that in the function and possibly also in the formation of germinal centers, one important factor is the localization of immune complexes with fixed complem...
متن کاملP-222: The Effect of Vitex Agnus Castus Essential Oil on Seminiferous Tubule Structure in Mice
Background: Plant materials continue to play an important role in the maintenance of human health since antiquity. Phytoestrogens are naturally occurring plant substances that can either mimic or antagonize the action of endogenous estrogens. This study was conducted to investigate the effects of vitex agnus as a phytoestrogenic plants, essential oil on structure and morphology of seminiferous ...
متن کاملHyperigM Syndrome
Somatic mutation of Ig variable regions occurs prominently in germinal centers, but it has been debated whether the mutation process initiates in germinal centers or is activated before germinal center entry of B cells. We have analyzed for the presence of somatic mutation in Ig gene rearrangements of the nonpolymorphic human VH6 gene in the X-linked HyperIgM syndrome, which is associated with ...
متن کاملBiology of IgE production: IgE cell differentiation and the memory of IgE responses.
The generation of long-lived plasma cells and memory B cells producing high-affinity antibodies depends on the maturation of B cell responses in germinal centers. These processes are essential for long-lasting antibody-mediated protection against infections. IgE antibodies are important for defense against parasites and toxins and can also mediate anti-tumor immunity. However, high-affinity IgE...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Developmental Immunology
دوره 6 شماره
صفحات -
تاریخ انتشار 1998